Thiol-Poly(ε-caprolactone) (PCL-SH), MW 5K is a thiol-functionalized poly(ε-caprolactone) with a molecular weight of approximately 5K. It combines a low-molecular-weight, biodegradable PCL backbone with terminal thiol functionality specifically for bioconjugation, polymer coupling, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Thiol-Functionalized PCL: Combines biodegradable poly(ε-caprolactone) with a terminal thiol group for chemical modification and conjugation.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Thiol Functionality: The terminal –SH group provides a reactive site specifically for thiol-selective coupling, surface attachment, and polymer modification.
- Biodegradable Polyester: The PCL backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Semicrystalline PCL Backbone: The PCL structure supports semicrystalline polymer formation and provides useful material-forming properties for biodegradable polymer research.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PCL grades.
- Versatile Conjugation Platform: The thiol terminus supports reactions with maleimide, vinyl sulfone, disulfide-forming reagents, and other thiol-reactive functional groups.
- Surface Affinity: Thiol functionality supports strong interactions with compatible metal surfaces, including gold, for surface modification and nanoparticle research.
Applications
- Bioconjugation: Supports thiol-selective attachment of PCL to compatible biomolecules, ligands, polymers, and other functional components.
- Thiol-Maleimide Coupling: Enables efficient conjugation with maleimide-functionalized molecules, polymers, and surfaces.
- Surface Modification: Provides terminal thiol functionality for attachment to compatible surfaces and materials.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related systems.
- Gold Surface Functionalization: Enables thiol-mediated attachment to gold surfaces and gold nanoparticles for material and interface research.
- Polymer Conjugation: Supports coupling with thiol-reactive polymers to prepare functional and multicomponent polymer architectures.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged exposure to air.
- Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
Thiol-Poly(ε-caprolactone) (PCL-SH), MW 5K provides a low-molecular-weight biodegradable PCL platform with terminal thiol functionality and good processability and specifically supports thiol-maleimide coupling, polymer conjugation, nanoparticle functionalization, gold surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.