TCO-PEG4-CH2 Acid
This high-purity PEG linker has a TCO for rapid, catalyst-free IEDDA cycloaddition with tetrazines and a terminal carboxylic acid for amine coupling. The PEG4 spacer specifically enhances solubility, flexibility, and reduces steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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TCO Group – Enables ultra-fast, catalyst-free tetrazine ligation for bioorthogonal labeling.
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Carboxylic Acid – Couples efficiently to primary amines via carbodiimide or other activation chemistries.
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PEG4 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible results.
Applications
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Bioorthogonal labeling of proteins, peptides, and nucleic acids
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Antibody–drug conjugate (ADC) linker chemistry
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Multifunctional imaging and diagnostic probe synthesis
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Nanoparticle and biomaterial surface functionalization
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to preserve reactivity
This product combines tetrazine ligation via TCO with a reactive carboxylic acid, connected by a PEG4 spacer for solubility and flexibility, making it especially ideal for precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
