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Copper free click chemistry linkers have been widely used for in vivo bioconjugation applications. Conventional “Click Chemistry” requires the presence of cytotoxic of Cu(I) catalyst, which limits its applications in biological systems. The Copper-free Click Chemistry is based on the reaction of a cyclooctyne (DBCO and BCN) moiety with an azide-labeled reaction partner, known as strain-promoted alkyne azide cycloaddition (SPAAC).

Copper Free Click Chemistry Linkers
  • BCN Linkers
  • DBCO Linkers
  • TCO Linkers
  • Tetrazine Linkers
Catalog# Name Structure M.W. Purity Pricing
Aminooxy-PEG-TCO
AP10141aminooxy-PEG2-TCO HCl Salt in solution373.45≥95% Pricing
AP10142Bocaminooxy-PEG2-TCO473.57≥95% Pricing
AP10105TCO-PEG2-oxyamine316.39≥95% Pricing
AP10104TCO-PEG3-oxyamine360.45≥95% Pricing
AP10107TCO-PEG2-oxyamineBoc416.51≥95% Pricing
AP10106TCO-PEG3-oxyamineBoc460.56≥95% Pricing
BCN Linkers
AP10754endo-BCN-PEG3-Biotin550.71≥95% Pricing
AP12383(1a,8a,9b)-Bicyclo[6.1.0]non-4-ene-9-methanol152.24≥95% Pricing
AP12382(Z,1R,8S,9r)-bicyclo[6.1.0]non-4-ene-9-methanol152.24≥95% Pricing
AP10548endo-BCN-NHS291.3≥95% Pricing
AP10970BCN-carbamate-PEG2-Bromide388.3≥95% Pricing
AP10616Bis-BCN-PEG1-diamide484.64≥95% Pricing
AP10617Bis-BCN-PEG3-diamide572.74≥95% Pricing
AP10611BCN-PEG1-OH194.27≥95% Pricing
AP10615Bis-BCN-pentanediamide482.67≥95% Pricing
AP10614BCN-PEG1-Br257.17≥95% Pricing
AP10610BCN-O-Acetic Acid208.26≥95% Pricing
AP12152Ethyl (1R,8S,9r)-bicyclo[6.1.0]non-4-ene-9-carboxylate194.27≥95% Pricing
AP10885Ethyl (1R,8S,9S,Z)-bicyclo[6.1.0]non-4-ene-9-carboxylate194.27≥95% Pricing
AP10109endo-BCN-Carbamido-Pentylamine278.39≥95% Pricing
AP10735exo BCN-PNPc315.32≥95% Pricing
AP10739BCN-endo-PEG3-Maleimide519.6≥95% Pricing
AP11022Folate-amido-C2-amine-BCN (endo)659.69≥95% Pricing
AP10612BCN-PEG1-OTs348.46≥95% Pricing
AP11024endo-BCN-PEG4-PNP534.56≥95% Pricing