Tert butyl ester-peg5-ch2cooh is a peg linker containing tertiary butyl protected carboxyl groups and terminal carboxylic acids. The terminal carboxylic acid can react with the primary amine group in the presence of an activator such as EDC or Hatu to form a stable amide bond. Hydrophilic peg spacers increase solubility in aqueous media. The carboxyl groups protected by tert butyl can be deprotected under acidic conditions.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.