Acid-PEG10-t-butyl ester is composed of three main functional groups: a carboxylic acid group, a PEG moiety, and a t-butyl ester group. The carboxylic acid group enables the molecule to participate in various coupling reactions, such as amide bond formation and esterification, providing a reactive site for conjugation to biomolecules like proteins, peptides, or small molecules. The PEG moiety, a 10-unit chain in this case, imparts hydrophilic properties to the molecule, improving its solubility and biocompatibility. The t-butyl ester group serves as a protective group for the carboxylic acid, ensuring stability during synthesis and purification. It can be easily removed under mild acidic conditions, unveiling the free carboxylic acid group for subsequent conjugation.
Acid-PEG10-t-butyl ester is widely utilized in bioconjugation reactions to modify biomolecules such as proteins, peptides, and antibodies,it can be employed to design prodrugs, where the active drug is released upon removal of the t-butyl ester group under specific conditions, such as enzymatic cleavage or changes in pH. This strategy allows for targeted drug release, minimizing unwanted side effects and improving drug potency.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.