2-((Azido-PEG8-carbamoyl)methoxy)acetic acid linker contains an azide group with a terminal carboxylic acid. The PEG spacer increases the aqueous solubility of the resulting compound. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.