Sulfo-DBCO-amine
This product is a water-soluble heterobifunctional linker containing a sulfonated dibenzocyclooctyne (DBCO) group and a primary amine. The sulfonated DBCO enables ultrafast, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides while maintaining excellent aqueous solubility. The amine group couples readily with carboxyls or activated esters, making this reagent especially effective for bioconjugation in biological environments.
Key Features and Benefits
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Sulfo-DBCO Group: Performs copper-free click chemistry with azides in aqueous conditions.
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Primary Amine: Couples efficiently with carboxyls or NHS esters to form amide bonds.
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Water Solubility: Sulfonated DBCO increases solubility for direct use in biological systems.
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Dual Reactivity: Supports orthogonal bioorthogonal ligation and classical amine coupling.
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High Purity: Manufactured to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links azide-modified biomolecules to carboxyl- or ester-functionalized partners.
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Protein and Antibody Labeling: Provides a dual-reactive handle for site-specific modification.
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Probe Development: Builds water-soluble clickable probes for imaging and diagnostics.
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Drug Delivery: Functions as a dual-functional linker for therapeutic conjugates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture-protected container.
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Handling: Use freshly prepared solutions; avoid prolonged exposure to aqueous buffers.
This product integrates copper-free click chemistry and amine coupling in a water-soluble scaffold, making it especially effective for biological conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
