SPDP-PEG5-acid is a bifunctional polyethylene glycol (PEG) linker featuring a pyridyldisulfide (SPDP) group and a carboxyl (-COOH) functional group. This versatile molecule is widely utilized in bioconjugation, allowing for thiol-reactive crosslinking and controlled conjugation of biomolecules. Furthermore, the PEG5 spacer enhances solubility, flexibility, and stability, making it an essential tool in drug delivery, protein modification, and nanotechnology applications.
Key Features
- Bifunctional Reactivity – Contains both a pyridyldisulfide group for thiol conjugation and a carboxyl group for amide coupling, thereby enabling diverse applications.
- Enhanced Solubility and Stability – The PEG5 spacer significantly increases hydrophilicity, reducing aggregation and improving stability in aqueous environments.
- Optimized Spacer Length – Provides a defined five-unit PEG linker, which ensures precise molecular spacing in bioconjugation applications.
- High Purity and Consistency – Manufactured under stringent quality controls, thus ensuring reproducibility in research and development.
- Versatile Conjugation – Suitable for modifying proteins, peptides, and nanoparticles, making it ideal for targeted biomedical applications.
Applications
- Bioconjugation and Crosslinking – Facilitates the attachment of biomolecules through thiol-reactive and amine coupling chemistries, thus broadening its applicability.
- Drug Delivery Systems – Enhances drug solubility and bioavailability, thereby improving therapeutic performance and efficacy.
- Protein and Peptide Modification – Enables site-specific labeling and conjugation, which is crucial for advanced biochemical studies.
- Nanoparticle and Surface Functionalization – Functionalizes surfaces and nanoparticles, making it highly beneficial for diagnostic and therapeutic applications.
Conclusion
In summary, SPDP-PEG5-acid is a highly efficient and versatile linker for bioconjugation, drug delivery, and protein modification. With its bifunctional reactivity, improved solubility, and optimized PEG5 spacer, this reagent provides a reliable and effective solution for researchers and developers in pharmaceutical and biotechnology fields. Therefore, its stability and precision make it an invaluable component in cutting-edge biomedical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
