SPDP-PEG8-acid linker contians SPDP crosslinker and carboxylic acid moieties. SPDP contains a cleavable disulfide bond and can react with amine and thiol groups. It is used for intracellular crosslinking process due to its’ excellent membrane permeability. The terminal caboxylic acid readily reacts primary or secondary amines under amide coupling conditions. The PEG spacer increase compound solubility in aqueous media.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.