SPDP-PEG-acid is a conjugate of PEG and succinimidyl-6-(3-(2-pyridyldithio) propionamido) hexanoate (SPDP), with a carboxylic acid functional group (-COOH) at the end of the PEG chain. The carboxylic acid group is known for its ability to react with other molecules through covalent bonding.
SPDP-PEG-acid has been extensively utilized in the development of drug delivery systems, bioconjugation, and surface modification of biomedical devices. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via amide bonds. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
SPDP-PEG-acid has also been employed as a surface modifier in various biomedical applications.
