Poly(L-Glutamic Acid)-PEG-N3 (pGlu-PEG-N3), MW x 7.5K, n 2K is a functional block copolymer composed of poly(L-glutamic acid) (pGlu) and polyethylene glycol (PEG) with a terminal azide (N3) group. This grade combines approximately 7.5K pGlu with 2K PEG, providing a strongly pGlu-rich architecture with carboxyl and azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines carboxyl-rich pGlu with hydrophilic PEG and terminal azide functionality for polymer modification and conjugation.
- pGlu MW 7.5K: Provides a substantial poly(amino acid) segment with abundant pendant carboxyl groups for molecular interactions and chemical modification.
- PEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility, hydration, and interfacial stabilization.
- Strongly pGlu-Rich Architecture: The 3.75:1 pGlu-to-PEG molecular weight ratio especially favors carboxyl-functional pGlu content while retaining a hydrophilic PEG component.
- Azide Functionality: Provides a terminal N3 group for click chemistry with compatible alkyne-functional molecules.
- Carboxyl-Rich Polymer: The pGlu block provides abundant pendant carboxyl groups for ionic interactions, functionalization, and conjugation.
- Versatile Conjugation Platform: Combines terminal azide functionality with pendant carboxyl groups to support multiple strategies for polymer modification and bioconjugation.
Applications
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkyne-functional molecules.
- Copper-Free Click Chemistry: Supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctyne groups.
- Bioconjugation: Enables attachment of peptides, proteins, ligands, and other biomolecules through azide-based click chemistry or carboxyl-group coupling.
- Polymer Functionalization: Provides azide and carboxyl groups for attachment of functional molecules and preparation of polymer conjugates.
- Drug Delivery: Supports development of functional polymer systems and modified drug-delivery carriers.
- Surface Functionalization: Enables click-based attachment of compatible molecules to polymeric surfaces and biomaterials.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for conjugates, coatings, hydrogels, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines carboxyl-rich pGlu, hydrophilic PEG, and terminal azide functionality in a strongly pGlu-rich block copolymer. It specifically supports click chemistry, bioconjugation, polymer functionalization, drug delivery, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
