Poly(L-Glutamic Acid)-PEG-N3 (pGlu-PEG-N3), MW x 3K, n 5K is a functional block copolymer composed of poly(L-glutamic acid) (pGlu) and polyethylene glycol (PEG) with a terminal azide (N3) group. This grade combines approximately 3K pGlu with 5K PEG, providing a PEG-rich architecture with carboxyl and azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines carboxyl-functional pGlu with hydrophilic PEG and terminal azide functionality for polymer modification and conjugation.
- pGlu MW 3K: Provides a poly(amino acid) segment with pendant carboxyl groups for molecular interactions and chemical modification.
- PEG MW 5K: Provides a substantial hydrophilic segment specifically for aqueous compatibility, hydration, and steric stabilization.
- PEG-Rich Architecture: The 3:5 pGlu-to-PEG molecular weight ratio especially favors hydrophilic PEG character while retaining substantial carboxyl-functional pGlu content.
- Azide Functionality: Provides a terminal N3 group for click chemistry with compatible alkyne-functional molecules.
- Carboxyl-Functional Polymer: The pGlu block provides pendant carboxyl groups for ionic interactions, functionalization, and conjugation.
- Versatile Conjugation Platform: Combines terminal azide functionality with pendant carboxyl groups to support multiple strategies for polymer modification and bioconjugation.
Applications
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkyne-functional molecules.
- Copper-Free Click Chemistry: Supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctyne groups.
- Bioconjugation: Enables attachment of peptides, proteins, ligands, and other biomolecules through azide-based click chemistry or carboxyl-group coupling.
- Polymer Functionalization: Provides azide and carboxyl groups for attachment of functional molecules and preparation of polymer conjugates.
- Drug Delivery: Supports development of functional polymer systems and modified drug-delivery carriers.
- Surface Functionalization: Enables click-based attachment of compatible molecules to polymeric surfaces and biomaterials.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for conjugates, coatings, hydrogels, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines carboxyl-functional pGlu, hydrophilic PEG, and terminal azide functionality in a PEG-rich block copolymer. It specifically supports click chemistry, bioconjugation, polymer functionalization, drug delivery, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
