pGlu-PEG-pGlu, MW x 3K, n 1K combines Poly(L-Glutamic Acid) (pGlu) blocks with a 1K polyethylene glycol (PEG) segment. This functional triblock copolymer provides multiple carboxyl groups specifically for conjugation, polymer modification, drug delivery research, and biomaterial development.
Key Features and Benefits
- Triblock Copolymer Structure: Combines pGlu and PEG in a pGlu-PEG-pGlu architecture for functional polymer research.
- pGlu MW 3K: The 3K pGlu component provides compact, carboxyl-rich polymer regions specifically for functionalization and conjugation studies.
- PEG MW 1K: The 1K PEG segment specifically provides a compact hydrophilic and flexible central polymer spacer.
- Carboxyl Functionality: Multiple pGlu side-chain carboxyl groups provide accessible sites for chemical modification.
- EDC/NHS Activation: Carboxyl groups specifically support carbodiimide-mediated activation and coupling with primary amines.
- pGlu-PEG-pGlu Architecture: pGlu blocks flank the hydrophilic PEG segment, providing multiple carboxyl groups for functionalization.
- Functionalizable Polymer Platform: Supports EDC/NHS coupling of pGlu carboxyl groups with amine-containing molecules.
Applications
- Bioconjugation: Carboxyl groups support conjugation with suitable amine-containing molecules.
- Drug Delivery Research: Useful for developing functional polymer systems for delivery and formulation studies.
- Polymer Functionalization: Supports modification with peptides, ligands, probes, and other amine-containing molecules.
- Nanoparticle Research: Suitable for developing functional polymeric nanoparticles and nanoscale assemblies.
- Controlled Release Research: Supports investigation of polymer-based controlled release and delivery systems.
- Polymer Conjugates: Useful for preparing pGlu-based conjugates through carboxyl activation chemistry.
- Biomaterial Research: Supports development of hydrophilic, carboxyl-rich functional polymer materials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
pGlu-PEG-pGlu, MW x 3K, n 1K provides a carboxyl-rich triblock architecture with a compact PEG segment and specifically supports bioconjugation, polymer functionalization, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.