PLGA Acid Capped, MW 5K is carboxyl-terminated poly(D,L-lactide-co-glycolide) with reactive terminal carboxylic acid groups. This biodegradable polymer possesses active -COOH terminals that support covalent bioconjugation with amine-modified peptides, small molecule drugs and biomacromolecules. With a molecular weight of 5,000 Da, it delivers moderate hydrolytic degradation rate compared to low-MW PLGA. It dissolves in common organic solvents including dichloromethane, THF, acetone and ethyl acetate, and is insoluble in water. The polymer degrades safely into lactic acid and glycolic acid inside organisms with low cytotoxicity. It is widely used to prepare functionalized PLGA nanoparticles, microspheres, polymer-drug conjugates for sustained release research. Store the product sealed at -20°C under dry, dark environment to avoid moisture-induced hydrolysis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.