PDLLA‑Acid (HOOC‑PDLLA‑COOH, MW 5K) is linear α,ω‑dicarboxyl‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeat units are randomly distributed along the polymer backbone, destroying stereoregularity and eliminating crystallinity. Compared with MW 2K PDLLA‑Acid, this 5 kDa grade exhibits higher hydrophobicity and slower homogeneous hydrolytic degradation profile. Dual terminal carboxylic acid groups can be activated by EDC/NHS carbodiimide chemistry to form stable amide bonds with amine‑bearing peptides, proteins, targeting ligands, fluorophores and small‑molecule drugs. It is a versatile bifunctional building block for block‑copolymer construction, bioconjugation, polymer‑drug conjugates and surface functional modification of nanoparticles/microspheres in biomedical research.
Key Features
- MW: 5000 Da, linear α,ω‑dicarboxyl‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Higher hydrophobicity, slower but still uniform hydrolysis versus 2K PDLLA‑Acid
- Good biocompatibility; degradation product is non‑toxic lactic acid
- Dual reactive‑COOH termini; EDC/NHS‑activatable for amide coupling with amine‑containing molecules
- Narrow molecular weight distribution, stable batch‑to‑batch reproducibility
- Soluble in DCM, CHCl₃, THF, DMF, acetone; insoluble in water
Applications
- Synthetic precursor for PDLLA‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑modified peptides, proteins, targeting moieties and fluorescent dyes after EDC/NHS activation
- Preparation of amide‑linked polymer‑drug conjugates for controlled‑release drug‑delivery research
- Carboxyl‑functional surface modification of nanoparticles, microspheres and biodegradable polymer films
- Synthetic intermediate for degradable polyester and polyurethane biomaterial fabrication
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere, strictly moisture‑proof
- Keep hermetically sealed; avoid moisture‑induced ester hydrolysis and side‑reactions; prohibit repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.