PDLLA‑Acid (HOOC‑PDLLA‑COOH, MW 10K) is linear α,ω‑dicarboxyl‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeating units are randomly distributed along polymer backbone, destroying stereoregularity without crystalline domains. Compared with MW 2K and 5K PDLLA‑Acid, this 10 kDa grade presents further increased hydrophobicity and markedly slower but still homogeneous hydrolytic degradation behaviour. Dual terminal‑COOH groups can be activated by EDC/NHS carbodiimide chemistry to form stable amide bonds with amine‑containing peptides, proteins, targeting ligands, fluorophores and small‑molecule therapeutics. It serves as a high‑molecular‑weight bifunctional building block for high‑performance block‑copolymer synthesis, bioconjugation, long‑acting polymer‑drug conjugates and surface functional modification of nanoparticles, microspheres and biodegradable films for biomedical research.
Key Features
- MW: 10000 Da, linear α,ω‑dicarboxyl‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Higher hydrophobicity, slower yet uniform hydrolysis compared with 2K / 5K PDLLA‑Acid
- Excellent biocompatibility; degradation product is non‑toxic lactic acid
- Dual reactive‑COOH termini; EDC/NHS‑activatable for amide coupling with amine‑bearing molecules
- Narrow molecular weight distribution, reliable batch‑to‑batch reproducibility
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
Applications
- Synthetic precursor for high‑molecular‑weight PDLLA‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑modified peptides, proteins, targeting moieties and fluorescent dyes after EDC/NHS activation
- Preparation of amide‑linked polymer‑drug conjugates for long‑term controlled‑release drug‑delivery research
- Carboxyl‑functional surface modification of nanoparticles, microspheres and thick biodegradable polymer films
- Synthetic intermediate for high‑performance degradable polyester and polyurethane biomaterials
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere, strictly keep away from moisture
- Keep hermetically sealed; avoid moisture‑triggered ester hydrolysis and side‑reactions; prohibit repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.