PDLLA-Acid (PDLLA-COOH), MW 20K is a carboxyl-functionalized poly(DL-lactide) with a molecular weight of approximately 20K. It combines a biodegradable amorphous PDLLA backbone with terminal carboxyl functionality specifically for bioconjugation, polymer functionalization, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Carboxyl-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal carboxyl group for chemical modification and conjugation.
- MW 20K: Provides a moderate molecular weight that balances polymer processability, biodegradable matrix formation, and functionalization.
- Carboxyl Functionality: The terminal –COOH group provides a reactive site specifically for coupling with amine-containing molecules through appropriate activation chemistry.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Amide Coupling Platform: The carboxyl terminus supports activation with EDC/NHS and other suitable coupling reagents for reaction with primary amines.
- Versatile Functionalization: Terminal carboxyl functionality specifically enables attachment of compatible polymers, biomolecules, peptides, proteins, ligands, and other functional components.
Applications
- Bioconjugation: Supports coupling of PDLLA with amine-containing biomolecules, peptides, proteins, ligands, and other functional components.
- EDC/NHS Coupling: Enables activation of the terminal carboxyl group for conjugation with primary amines.
- Amide Bond Formation: Supports formation of stable amide linkages with compatible amine-functionalized molecules and materials.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables incorporation of carboxyl functionality into PDLLA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Acid (PDLLA-COOH), MW 20K provides an amorphous biodegradable PDLLA platform with terminal carboxyl functionality for versatile conjugation and functionalization and specifically supports bioconjugation, polymer modification, nanoparticle functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.