PDLLA‑Acid (HOOC‑PDLLA‑COOH, MW 20K) is linear α,ω‑dicarboxyl‑terminated fully amorphous biodegradable aliphatic polyester. Random distribution of D‑lactide and L‑lactide units along the polymer backbone eliminates stereoregularity and crystalline domains. Within the PDLLA‑Acid 2K‑20K series, this 20 kDa grade possesses the highest hydrophobicity and exhibits extremely slow yet homogeneous hydrolytic degradation behaviour. Dual terminal carboxylic acid groups can be activated by EDC/NHS carbodiimide chemistry to form stable amide bonds with amine‑bearing peptides, proteins, targeting ligands, fluorophores and small‑molecule therapeutics. As a high‑molecular‑weight bifunctional macro‑initiator and building block, it is widely applied for high‑performance block‑copolymer synthesis, bioconjugation, ultra‑long‑acting polymer‑drug conjugates, and surface functional modification of nanoparticles, microspheres and dense biodegradable films in biomedical research.
Key Features
- MW: 20000 Da, linear α,ω‑dicarboxyl‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Highest hydrophobicity in PDLLA‑Acid 2K‑20K series, ultra‑slow but uniform hydrolytic degradation
- Excellent biocompatibility; hydrolytic degradation yields non‑toxic lactic‑acid metabolites
- Dual reactive‑COOH termini; EDC/NHS‑activatable for amide coupling with amine‑containing molecules
- Narrow molecular weight distribution, excellent batch‑to‑batch consistency
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
Applications
- Synthetic precursor for high‑molecular‑weight PDLLA‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑modified peptides, proteins, targeting moieties and fluorescent dyes after EDC/NHS activation
- Preparation of amide‑linked polymer‑drug conjugates for ultra‑long‑term controlled‑release drug‑delivery research
- Carboxyl‑functional surface modification of nanoparticles, microspheres and dense biodegradable polymer films
- Synthetic intermediate for high‑performance degradable polyester and polyurethane biomaterials
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere, strictly moisture‑proof
- Keep hermetically sealed; avoid moisture‑triggered ester hydrolysis and side‑reactions; prohibit repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.