PCL-PEG-NH2 is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal primary amine. This grade combines approximately 5K PCL with 3K PEG. Its PCL-rich architecture supports hydrophobic assembly, while the NH2 group enables bioconjugation and functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 5K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic drug incorporation.
- PEG MW 3K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PCL-Rich Architecture: The higher PCL-to-PEG ratio supports hydrophobic interactions and amphiphilic self-assembly.
- Amine Functionalization: Provides a terminal primary amine specifically for conjugation and chemical modification.
- Reactive NH2 Group: Supports coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
Applications
- Bioconjugation: Enables attachment of peptides, targeting ligands, probes, and other functional molecules.
- Nanoparticle Research: Supports functionalized nanoparticles, micelles, and other amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Surface Functionalization: Provides a reactive amine for introducing targeting ligands and functional groups.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and amine functionality.
PCL-PEG-NH2, MW x 5K, n 3K combines a hydrophobic PCL block with hydrophilic PEG and terminal amine functionality that specifically supports polymer self-assembly, bioconjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.