PCL-PEG-Maleimide (PCL-PEG-Mal), MW x 3K, n 3K is a thiol-reactive amphiphilic block copolymer composed of poly(ε-caprolactone), polyethylene glycol, and a terminal maleimide group. The equal 3K PCL and 3K PEG blocks provide balanced hydrophobic-hydrophilic character for polymer assembly, while maleimide enables selective conjugation with thiol-containing molecules.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly, functionalization, and drug delivery.
- PCL MW 3K: Provides a biodegradable hydrophobic segment specifically for core formation and hydrophobic cargo incorporation.
- PEG MW 3K: Provides a hydrophilic segment for aqueous compatibility, surface hydration, and steric stabilization.
- Balanced Block Ratio: Equal PCL and PEG molecular weights provide balanced hydrophobic and hydrophilic character for amphiphilic assembly.
- Maleimide Functionalization: Provides a terminal maleimide group for selective reaction with free sulfhydryl groups.
- Thiol Conjugation: Maleimide reacts with thiol-containing molecules to form stable covalent thioether linkages under suitable conditions.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, antibodies, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and other polymer assemblies.
- Drug Delivery: Supports functionalized polymeric carriers specifically for targeted and controlled drug delivery research.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands to PEG-presenting polymeric carriers.
- Surface Functionalization: Supports preparation of maleimide-presenting biomaterials and polymer surfaces for thiol coupling.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged exposure to aqueous or strongly basic conditions that may hydrolyze maleimide functionality.
This product combines balanced PCL and PEG blocks with thiol-reactive maleimide functionality and specifically supports amphiphilic assembly, biomolecule conjugation, nanoparticle surface modification, and targeted drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.