PCL-PEG-Maleimide (PCL-PEG-Mal), MW x 5K, n 3K is a thiol-reactive amphiphilic block copolymer composed of poly(ε-caprolactone), polyethylene glycol, and a terminal maleimide group. The 5K PCL block provides a hydrophobic domain for self-assembly and cargo incorporation, while the 3K PEG block provides aqueous stabilization and presents maleimide for selective conjugation with thiol-containing molecules.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly, functionalization, and drug delivery.
- PCL MW 5K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic cargo incorporation.
- PEG MW 3K: Provides a hydrophilic segment specifically for aqueous compatibility, surface hydration, and steric stabilization.
- PCL-Rich Architecture: The 5:3 PCL-to-PEG molecular weight ratio supports hydrophobic core formation while retaining PEG-mediated surface stabilization.
- Maleimide Functionalization: Provides a terminal maleimide group for selective reaction with free sulfhydryl groups.
- Thiol Conjugation: Maleimide reacts with thiol-containing molecules to form stable covalent thioether linkages under suitable conditions.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, antibodies, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and other polymer assemblies.
- Drug Delivery: Supports hydrophobic cargo incorporation and functionalized polymeric carrier development.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands to PEG-presenting polymeric carriers.
- Surface Functionalization: Supports preparation of maleimide-presenting biomaterials and polymer surfaces for thiol coupling.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged exposure to aqueous or strongly basic conditions that may hydrolyze maleimide functionality.
This product combines a PCL-rich amphiphilic architecture with thiol-reactive maleimide functionality and specifically supports hydrophobic drug incorporation, biomolecule conjugation, nanoparticle surface modification, and targeted drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.