PCL-PEG-Maleimide (PCL-PEG-Mal), MW x 10K, n 2K is an amphiphilic functional block copolymer. It combines a 10K poly(ε-caprolactone) (PCL) block with a 2K polyethylene glycol (PEG) block. Its PCL-rich architecture supports hydrophobic assembly and drug incorporation while the terminal maleimide provides a reactive site for thiol-selective conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 10K: Provides a substantial biodegradable hydrophobic block specifically for core formation and hydrophobic drug incorporation.
- PEG MW 2K: Provides a shorter hydrophilic segment specifically for aqueous compatibility and interfacial stabilization.
- PCL-Rich Architecture: The 5:1 PCL-to-PEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies.
- Maleimide Functionalization: Provides a terminal maleimide group for efficient thiol-selective conjugation.
- Thiol-Reactive: Maleimide reacts with sulfhydryl groups to form covalent thioether linkages under suitable reaction conditions.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, antibodies, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and other polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and targeted drug delivery research.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands and other sulfhydryl-containing molecules.
- Biomaterial Research: Supports development of functionalized and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid conditions that can hydrolyze or degrade maleimide functionality.
PCL-PEG-Maleimide (PCL-PEG-Mal), MW x 10K, n 2K combines a PCL-rich architecture with thiol-reactive maleimide functionality that specifically supports targeted conjugation, hydrophobic drug delivery, nanoparticle functionalization, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.