PC-Biotin-PEG4-NHS carbonate
This product is a heterobifunctional linker featuring a photocleavable (PC) group, a biotin moiety for avidin/streptavidin binding, and an NHS carbonate for amine conjugation. The PEG4 spacer specifically improves solubility and spacing, making this reagent highly useful in photo-controlled bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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Photocleavable Group: Enables light-triggered, reversible conjugation control.
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Biotin Moiety: Provides high-affinity binding to avidin/streptavidin.
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NHS Carbonate: Couples efficiently with primary and secondary amines.
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PEG4 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Photo-Controlled Bioconjugation: Enables spatiotemporal release of biotinylated conjugates.
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Probe Development: Builds cleavable probes for imaging and diagnostics.
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Drug Delivery: Supports light-triggered release strategies in therapeutic systems.
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Bioconjugation: Couples amine-containing biomolecules with biotin for enrichment and detection.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure to preserve PC activity.
This product combines photocleavable chemistry with biotin affinity and amine-reactive conjugation, offering especially versatile use in probe design, controlled release, and advanced bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
