Methyltetrazine-PEG6-Maleimide is a heterobifunctional linker featuring tetrazine for bioorthogonal IEDDA reactions and maleimide for thiol-specific conjugation, connected by a PEG spacer. The hydrophilic PEG6 spacer enhances solubility and reduces steric hindrance, ensuring efficient bioconjugation.
Key Features
- Methyltetrazine Group
Enables rapid, selective bioorthogonal reactions with strained alkenes (e.g., trans-cyclooctene). - Maleimide Group
Reacts specifically with thiol groups in proteins, peptides, or other biomolecules. - PEG6 Spacer
Improves solubility, flexibility, and reduces steric interference in reactions.
Methyltetrazine-PEG6-Maleimide Applications
- Bioconjugation
Enables precise labeling of biomolecules for research or therapeutic purposes. - Drug Delivery Systems
Facilitates targeted therapeutic conjugates through thiol-specific attachment. - Molecular Imaging
Supports the development of functional probes for diagnostics. - Material Functionalization
Ideal for modifying nanoparticles, polymers, or surfaces.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
