Methyltetrazine-PEG4-Hydrazone-DBCO is a multifunctional linker combining methyltetrazine for bioorthogonal click chemistry, a hydrazone group for reversible pH-sensitive conjugation, and DBCO (Dibenzocyclooctyne) for strain-promoted azide-alkyne cycloaddition (SPAAC). Its PEG4 spacer ensures high solubility and reduced steric hindrance.
Key Features
- Methyltetrazine Group
Enables fast, selective IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - Hydrazone Linkage
Provides pH-sensitive, reversible conjugation for controlled release. - DBCO Group
Facilitates copper-free click chemistry with azides, allowing for biocompatible labeling. - PEG4 Spacer
Enhances water solubility and minimizes steric effects.
Applications
- Dual Bioorthogonal Conjugation
Supports sequential or orthogonal labeling of biomolecules. - Targeted Drug Delivery
Enables pH-triggered drug release and precise targeting. - Bioconjugation and Imaging
Ideal for site-specific labeling and probe development. - Nanomaterial Functionalization
Useful in modifying nanoparticles or surfaces with dual reactivity.
Short Description
Methyltetrazine-PEG4-Hydrazone-DBCO is a trifunctional linker with methyltetrazine for IEDDA reactions, hydrazone for pH-sensitive conjugation, and DBCO for azide-alkyne click chemistry. It is ideal for bioconjugation, imaging, and controlled drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
