Methyltetrazine Oxyamine is a reactive compound designed for bioorthogonal chemistry applications. It features a methyltetrazine group for fast, copper-free inverse electron demand Diels-Alder (IEDDA) reactions with trans-cyclooctene (TCO) and an oxyamine group that reacts with aldehydes and ketones via oxime ligation. This dual reactivity makes it ideal for precise labeling and conjugation in chemical biology and biomolecular research.
Key Features
- Dual Functional Groups:
- Methyltetrazine: Enables fast and selective bioorthogonal reactions with TCO-containing molecules.
- Oxyamine: Reacts efficiently with aldehydes and ketones to form stable oxime bonds.
- Versatility:
- Suitable for multi-functional conjugation and labeling in aqueous environments.
- Facilitates copper-free, biocompatible reactions.
- Biocompatibility:
- Non-toxic and compatible with live-cell and in vivo systems.
Methyltetrazine Oxyamine Applications
- Bioconjugation:
- Labels proteins, peptides, and nucleic acids with high specificity.
- Drug Delivery:
- Acts as a linker for dual-functional drug delivery systems.
- Chemical Biology:
- Supports rapid, site-specific labeling and complex molecule assembly.
- Diagnostics:
- Enables efficient conjugation of biomolecules for sensor and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
