Methyltetrazine-O-PEG12-amine HCl salt
This product is a methyltetrazine-functionalized PEGylated amine (PEG12) specifically presented as the HCl salt. The methyltetrazine enables ultrafast inverse-electron-demand Diels–Alder (IEDDA) ligations with TCO/strained alkenes, while PEG12 delivers aqueous solubility and spacing for reduced steric hindrance.
Key Features and Benefits
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Methyltetrazine Group: Enables rapid, bioorthogonal IEDDA ligation with trans-cyclooctene (TCO) and other strained alkenes for fast, catalyst-free conjugation.
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PEG12 Spacer: Provides hydrophilicity, flexibility, and reduced aggregation — improves solubility and accessibility of the reactive tetrazine.
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Terminal Amine (HCl salt): Primary amine enables standard amide- and carbamate-forming chemistries; HCl salt improves shelf stability and water solubility.
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Fast Kinetics & Selectivity: Especially ideal for fast labeling in complex biological environments with minimal off-target reactivity.
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High Purity: Synthesized and purified to ≥95% to ensure reproducible conjugation performance.
Applications
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Bioconjugation: Rapidly label proteins, antibodies, peptides, and nucleic acids using TCO-modified partners.
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Live-cell & In vivo Labeling: Fast, bioorthogonal reactions suitable for cell-surface labeling, imaging, and tracking.
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Antibody-Drug Conjugates (ADCs): Site-selective payload attachment using tetrazine–TCO chemistry.
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Probe & Imaging Agent Construction: Build fluorescent probes, PET tracers, and targeted imaging agents.
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Surface & Material Functionalization: Functionalize nanoparticles, hydrogels, or sensor surfaces for downstream capture or detection.
Storage and Handling
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Storage: Store at −20 °C in a sealed, desiccated container, protected from light.
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Handling: Minimize exposure to moisture and strong nucleophiles; handle under low-light conditions. Prepare fresh working solutions and avoid prolonged storage in protic solvents.
This product combines ultrafast tetrazine reactivity with PEG-mediated solubility and a versatile amine handle, making it especially ideal for rapid, bioorthogonal labeling and conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
