Maleimide-Poly(ε-caprolactone) (PCL-Maleimide), MW 5K is a maleimide-functionalized poly(ε-caprolactone) with a molecular weight of approximately 5K. It combines a low-molecular-weight, biodegradable PCL backbone with terminal maleimide functionality specifically for thiol-selective conjugation, bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
Key Features and Benefits
- Maleimide-Functionalized PCL: Combines biodegradable poly(ε-caprolactone) with a terminal maleimide group for selective chemical modification and conjugation.
- MW 5K: Provides a low molecular weight with good processability for polymer functionalization, formulation, and conjugation research.
- Maleimide Functionality: The terminal maleimide group provides a reactive site specifically for selective coupling with thiol-containing molecules under appropriate reaction conditions.
- Thiol-Reactive Platform: Supports thiol-maleimide coupling to form stable covalent linkages with compatible thiol-functionalized molecules and materials.
- Biodegradable Polyester: The PCL backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Semicrystalline PCL Backbone: The PCL structure supports semicrystalline polymer formation and also provides useful material-forming properties for biodegradable polymer research.
- Good Processability: The low molecular weight specifically facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PCL grades.
- Versatile Conjugation Platform: Maleimide functionality enables attachment of compatible thiol-containing peptides, proteins, ligands, polymers, and other functional components.
Applications
- Thiol-Maleimide Coupling: Supports selective conjugation with thiol-functionalized molecules and materials.
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, ligands, and other compatible biomolecules.
- Polymer Functionalization: Supports preparation of functional PCL derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Enables functionalization of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Supports incorporation of maleimide functionality into PCL-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Ligand Conjugation: Enables attachment of compatible thiol-containing targeting ligands and functional molecules.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat because maleimide groups can undergo hydrolysis under inappropriate conditions. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
Maleimide-Poly(ε-caprolactone) (PCL-Maleimide), MW 5K provides a low-molecular-weight biodegradable PCL platform with terminal maleimide functionality and good processability and specifically supports thiol-selective conjugation, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.