As a high‑molecular‑weight reactive polyester in the PCL‑Maleimide series, this 10 kDa polymer features significantly extended aliphatic chain length, higher crystallinity and enhanced structural rigidity compared to medium and low‑MW counterparts. Its terminal maleimide group retains high thiol‑selective Michael‑addition reactivity, enabling stable covalent conjugation with cysteine‑modified proteins, peptides and targeting ligands. Benefiting from reduced hydrolysis rate and strong chain cohesion, this PCL‑Maleimide grade delivers outstanding colloidal and structural stability under prolonged biological environments. It is specially developed for long‑term circulating nanoparticle carriers, durable surface functionalization and in‑vivo studies requiring sustained structural retention, filling the performance gap between medium‑cycle 5K and ultra‑long‑cycle 15K/20K maleimide‑terminated PCL materials.
Key Features:
- High‑crystallinity long‑chain PCL backbone with terminal maleimide functionality, ensuring excellent structural stability in complex biological media
- Greatly slowed hydrolytic degradation rate, supporting month‑level sustained release and long‑term in vivo residence without rapid matrix collapse
- Strong chain entanglement enhances nanoparticle mechanical robustness, resisting dissociation and premature drug leakage during circulation
- Strict pH‑tunable thiol specificity (pH 6.0–7.4), effectively avoiding non‑specific crosslinking with amine groups in complex biomolecule systems
- High end‑group purity and consistent maleimide functionalization rate, ensuring reliable and repeatable bioconjugation experimental results
Applications:
- Construction of long‑circulation thiol‑functionalized polymeric nanoparticles and micelles for sustained drug delivery research
- Durable surface modification of implantable electrospun scaffolds and polymer films for long‑term tissue engineering studies
- Preparation of stable polymer‑antibody and polymer‑peptide conjugates for targeted in vivo delivery and biodistribution evaluation
- Development of long‑acting functional coating materials for biosensors requiring prolonged biological stability
- Preclinical formulation validation of durable targeted carrier systems for mid‑long term animal experimental models
Handling & Storage: Store the lyophilized polymer at −20 °C under dry, oxygen‑free inert atmosphere and avoid light exposure. Maleimide groups are sensitive to humidity and prone to hydrolysis and deactivation. Allow the sealed vial to fully equilibrate to room temperature in a desiccator before opening to prevent condensation contamination. Prepare polymer solutions freshly with anhydrous organic solvents prior to use; prolonged storage of dissolved stock solutions is not recommended. This product is for scientific research only and is not approved for clinical or human in vivo use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.