BCN-PEG12-Acid
Description:
BCN-PEG12-Acid is a versatile linker with a BCN group and a terminal carboxylic acid. The BCN group reacts quickly with azide-functionalized biomolecules through copper-free click chemistry. The carboxylic acid end readily forms stable amide bonds with amine groups using coupling reagents like EDC, DCC, and HATU. The PEG12 spacer enhances solubility and reduces non-specific binding.
Key Features:
- BCN Group: Enables fast, catalyst-free reactions with azides for efficient labeling.
- PEG12 Linker: Boosts solubility and biocompatibility of bioconjugates.
- Carboxylic Acid: Reacts with amines to form stable bonds using common coupling agents.
Applications:
- Bioorthogonal Labeling: Ideal for copper-free click chemistry with azides, perfect for live-cell and in vivo studies.
- Bioconjugation: Links proteins, peptides, and other biomolecules to surfaces or carriers for diagnostics and therapeutics.
- Surface Modification: Enhances surface properties and reduces fouling with the PEG spacer.
Benefits:
- Fast and Specific: BCN group ensures rapid and selective conjugation under mild conditions.
- Improved Solubility: PEG12 minimizes non-specific interactions and increases water solubility.
- Dual Reactivity: Combines BCN’s click chemistry with carboxylic acid’s amine reactivity for versatile conjugation options.
Summary:
BCN-PEG12-Acid combines BCN’s efficient click chemistry with a versatile carboxylic acid, offering dual functionality for bioconjugation and labeling. The PEG spacer enhances solubility, making it ideal for advanced biochemistry and surface modifications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
