This product is a thiol-functionalized phospholipid featuring a hydrophobic DSPE lipid anchor and reactive sulfhydryl (–SH) functionality. The thiol group specifically supports selective conjugation, surface attachment, and functionalization of lipid-based materials.
Key Features and Benefits
- Thiol-Functionalized Phospholipid: DSPE-Thiol (DSPE-SH) provides reactive sulfhydryl functionality for conjugation and material modification.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into compatible lipid membranes and assemblies.
- Thiol Functionality: The –SH group specifically provides a reactive site for coupling with compatible thiol-reactive molecules.
- Maleimide-Reactive Chemistry: Thiols readily react with maleimide groups under suitable conditions to form stable thioether linkages.
- Metal Surface Affinity: Thiol functionality supports attachment to compatible metal surfaces, including gold-based nanomaterials.
- Amphiphilic Character: The DSPE structure supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Surface Functionalization: DSPE-SH provides thiol functionality at lipid interfaces for further chemical modification.
- Functional Lipid Platform: The combination of a DSPE anchor and thiol group supports diverse bioconjugation and biomaterial applications.
Applications
- Thiol Conjugation: DSPE-Thiol (DSPE-SH) supports coupling with maleimide and other compatible thiol-reactive groups.
- Bioconjugation: Provides reactive sulfhydryl functionality for attaching compatible biomolecules, probes, and ligands.
- Liposome Functionalization: Enables incorporation of thiol-functionalized phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a functional lipid component specifically for experimental lipid nanoparticle formulations.
- Gold Nanoparticle Research: Thiol functionality supports attachment to compatible gold surfaces and nanomaterials.
- Nanoparticle Functionalization: Supports introduction of reactive thiol groups into compatible lipid-containing nanoparticle systems.
- Surface Modification: Enables thiol-mediated modification of compatible surfaces and material interfaces.
- Biomaterial Research: Supports development of functional lipid assemblies, conjugates, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged exposure to air to reduce oxidation of thiol groups.
This product combines a hydrophobic DSPE lipid anchor with reactive thiol functionality and specifically provides a versatile platform for maleimide coupling, surface attachment, bioconjugation, and lipid functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
