This product is an amine-reactive phospholipid featuring a hydrophobic DSPE lipid anchor and reactive N-hydroxysuccinimide (NHS) ester functionality, while the NHS ester supports efficient conjugation with primary amines to form stable amide bonds.
Key Features and Benefits
- Amine-Reactive Phospholipid: Provides NHS ester functionality for conjugation with primary amines.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into compatible lipid membranes and assemblies.
- NHS Ester Functionality: The reactive NHS ester provides a convenient site for coupling with amine-containing molecules.
- Amine-Reactive Chemistry: DSPE-NHS reacts with suitable primary amines under appropriate conditions.
- Stable Amide Formation: NHS ester coupling with primary amines produces stable covalent amide linkages.
- Amphiphilic Character: The DSPE structure supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Surface Functionalization: DSPE-NHS provides amine-reactive functionality at lipid interfaces for further modification.
- Functional Lipid Platform: The combination of a DSPE anchor and NHS ester supports diverse conjugation and biomaterial applications.
Applications
- Amine Conjugation: DSPE-NHS (DSPE-NHS Ester) supports covalent coupling with compatible primary amine-containing molecules.
- Bioconjugation: Enables attachment of suitable peptides, proteins, probes, and other amine-containing biomolecules.
- Ligand Conjugation: Supports covalent attachment of amine-containing ligands through stable amide bonds.
- Liposome Functionalization: Enables incorporation of amine-reactive phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a functional lipid component specifically for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports attachment of amine-containing molecules to compatible lipid-containing nanoparticles.
- Surface Modification: Provides NHS ester functionality for modification of compatible lipid and material interfaces.
- Biomaterial Research: Supports development of functional lipid conjugates, assemblies, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: NHS esters are moisture sensitive and can hydrolyze in aqueous environments. Minimize exposure to moisture and prepare aqueous solutions shortly before use.
This product combines a hydrophobic DSPE lipid anchor with reactive NHS ester functionality and specifically provides a versatile platform for amine coupling, bioconjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
