DSPE-PEG-NHS, MW 10K is an amphiphilic phospholipid-PEG conjugate containing a terminal N-hydroxysuccinimide (NHS) ester and specifically combines a hydrophobic DSPE lipid anchor with hydrophilic 10K PEG and amine-reactive functionality for bioconjugation, lipid assembly, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSPE-PEG-NHS combines hydrophobic DSPE with hydrophilic PEG in one functional conjugate.
- PEG MW 10K: The 10K PEG segment provides a long hydrophilic spacer between the lipid anchor and reactive NHS ester.
- DSPE Lipid Anchor: The phospholipid segment specifically supports incorporation into lipid membranes, liposomes, and compatible nanostructures.
- NHS Ester Functionality: The terminal NHS ester specifically provides a reactive site for coupling with primary amines.
- Amine-Reactive Chemistry: NHS ester chemistry specifically supports formation of stable amide bonds with compatible amine-containing molecules.
- Bioconjugation Capability: Supports conjugation with peptides, proteins, amino-functionalized molecules, and other compatible ligands.
- PEGylated Lipid Platform: The PEG segment specifically supports development of functional PEG-containing lipid assemblies and nanoparticle surfaces.
- Functional Conjugation Platform: Combines lipid anchoring, PEG spacing, and amine-reactive functionality within one material.
Applications
- Amine Conjugation: Researchers use DSPE-PEG-NHS, MW 10K to couple primary amine-containing molecules through amide bond formation.
- Bioconjugation: Supports conjugation with peptides, proteins, ligands, and other amine-containing biomolecules.
- Liposome Functionalization: Enables introduction of functional molecules onto PEGylated liposome surfaces.
- Nanoparticle Functionalization: Supports surface modification of lipid-based and compatible nanoparticle systems.
- Lipid Assembly Research: Enables studies of functional PEG-lipid incorporation into membranes and nanoscale assemblies.
- Ligand Conjugation: Supports attachment of compatible amine-containing ligands to PEGylated lipid systems.
- Surface Modification: Provides a PEG spacer and terminal NHS ester for amine-mediated surface functionalization.
- Biomaterial Research: Supports development of functional lipid-polymer assemblies, conjugates, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. NHS esters are moisture sensitive and can hydrolyze in aqueous environments. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-PEG-NHS, MW 10K combines a DSPE lipid anchor, hydrophilic 10K PEG spacer, and amine-reactive NHS ester and specifically supports bioconjugation, liposome functionalization, nanoparticle modification, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
