DSPE‑PEG‑OPSS, MW 1000
DSPE‑PEG‑OPSS (MW 1000) (full name: 1,2‑distearoyl‑sn‑glycero‑3‑phosphoethanolamine‑N‑[polyethylene glycol‑1000]‑orthopyridyl disulfide, abbreviated as DSPE‑PEG1000‑OPSS) is an amphiphilic, heterobifunctional PEG‑lipid conjugate.
Core Structure
- Hydrophobic domain: DSPE (1,2‑distearoyl‑sn‑glycero‑3‑phosphoethanolamine), a saturated C18 phospholipid that stably inserts into lipid bilayers.
- Hydrophilic spacer: A PEG‑1000 chain, providing water solubility and moderate steric stabilization.
- Reactive end: An orthopyridyl disulfide (OPSS) group, which selectively reacts with thiol (‑SH) groups via disulfide exchange.
Key Properties
- Appearance: White to off‑white solid/powder.
- Solubility: Soluble in DMSO, DMF, chloroform; dispersible in aqueous solutions.
- Purity: Typically ≥95%.
- Storage: −20 °C, desiccated, protected from light; avoid repeated freeze‑thaw cycles.
Main Applications
- Liposome & LNP PEGylation: Inserts into lipid membranes to improve colloidal stability and reduce non‑specific protein adsorption.
- Thiol‑specific bioconjugation: Reacts with thiolated peptides, antibodies, proteins, or ligands to form reversible disulfide bonds.
- Redox‑responsive delivery: Disulfide linkages cleave in high‑glutathione environments (e.g., tumor cells), enabling controlled release.
- Surface functionalization: Used for targeted drug delivery and nanocarrier modification in biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
