This product is an amphiphilic phospholipid-PEG conjugate containing a terminal maleimide group and specifically combines a hydrophobic DSPE lipid anchor with a short 600 MW PEG spacer and thiol-reactive functionality for conjugation and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSPE-PEG-Maleimide combines hydrophobic DSPE with a hydrophilic PEG segment in one functional conjugate.
- PEG MW 600: The 600 MW PEG segment specifically provides a short hydrophilic spacer between DSPE and the terminal maleimide.
- DSPE Lipid Anchor: The phospholipid segment specifically supports incorporation into lipid membranes, liposomes, and compatible nanostructures.
- Maleimide Functionality: The terminal maleimide specifically provides a reactive site for coupling with thiol-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with free thiols under suitable conditions to form stable thioether linkages.
- Bioconjugation Capability: Supports conjugation with cysteine-containing peptides, proteins, and other thiol-functionalized molecules.
- Compact PEG Spacer: The short PEG chain provides separation between the lipid anchor and maleimide while maintaining a compact molecular architecture.
- Functional Lipid Platform: Combines lipid anchoring, PEG spacing, and thiol-reactive functionality within one material.
Applications
- Thiol Conjugation: Researchers use DSPE-PEG-Maleimide, MW 600 to couple thiol-containing molecules through maleimide chemistry.
- Bioconjugation: Supports conjugation with cysteine-containing peptides, proteins, and other thiol-bearing biomolecules.
- Liposome Functionalization: Enables attachment of thiol-containing molecules to functionalized lipid and liposome systems.
- Nanoparticle Functionalization: Supports surface modification of lipid-based and compatible nanoparticle systems.
- Ligand Conjugation: Enables attachment of thiol-containing ligands to DSPE-containing lipid assemblies.
- Lipid Assembly Research: Supports incorporation of functional PEG-lipids into membranes and nanoscale assemblies.
- Surface Modification: Provides a short PEG spacer and terminal maleimide for thiol-mediated surface functionalization.
- Biomaterial Research: Supports development of functional lipid assemblies, conjugates, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged exposure to aqueous conditions before conjugation to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
This product combines a DSPE lipid anchor, short PEG spacer, and thiol-reactive maleimide functionality and specifically supports thiol conjugation, lipid functionalization, nanoparticle modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
