DSPE‑PEG‑Maleimide, MW 600
DSPE‑PEG‑Maleimide (MW 600) (full name: 1,2‑Distearoyl‑sn‑glycero‑3‑phosphoethanolamine‑N‑[maleimide(polyethylene glycol)‑600], abbreviated as DSPE‑PEG600‑Mal) is an amphiphilic, heterobifunctional PEG‑lipid conjugate.
Core Structure
- Hydrophobic domain: DSPE (1,2‑distearoyl‑sn‑glycero‑3‑phosphoethanolamine), a saturated C18 phospholipid that acts as a stable membrane anchor.
- Hydrophilic spacer: A short PEG‑600 chain, providing moderate water solubility and steric stabilization.
- Reactive end: A maleimide (Mal) group, highly specific for thiol (‑SH) conjugation.
Key Properties
- Appearance: White to off‑white solid/powder.
- Solubility: Soluble in organic solvents (DMSO, DMF, chloroform) and dispersible in aqueous solutions.
- Purity: Typically ≥95%.
- Storage: −20 °C, desiccated, protected from light.
Main Applications
- Liposome & Nanoparticle PEGylation: Inserts into lipid bilayers to form stealth surfaces, reducing non‑specific protein adsorption and extending circulation time.
- Targeted Delivery: The maleimide group enables site‑specific conjugation to thiol‑containing ligands, antibodies, peptides, or proteins under neutral conditions.
- Self‑Assembly: Forms stable micelles or liposomes for encapsulating hydrophobic drugs.
- Surface Modification: Used for functionalizing lipid‑based nanocarriers in drug delivery and biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
