DSPE-Maleimide (DSPE-Mal) is a thiol-reactive phospholipid featuring a hydrophobic DSPE lipid anchor and maleimide functionality, while the maleimide group supports selective coupling with sulfhydryl groups to form stable thioether linkages.
Key Features and Benefits
- Maleimide-Functionalized Phospholipid: DSPE-Maleimide (DSPE-Mal) provides reactive maleimide functionality for thiol-selective conjugation.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that support incorporation into compatible lipid membranes and assemblies.
- Maleimide Functionality: The maleimide group provides a reactive site specifically for coupling with sulfhydryl-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with suitable thiols under appropriate conditions.
- Stable Thioether Formation: Maleimide-thiol coupling specifically produces stable covalent thioether linkages.
- Amphiphilic Character: The DSPE structure specifically supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Surface Functionalization: DSPE-Mal provides thiol-reactive functionality at lipid interfaces for further modification.
- Functional Lipid Platform: The combination of a DSPE anchor and maleimide supports diverse bioconjugation and biomaterial applications.
Applications
- Thiol Conjugation: DSPE-Maleimide (DSPE-Mal) supports selective coupling with compatible sulfhydryl-containing molecules.
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, probes, and other biomolecules.
- Ligand Conjugation: Supports covalent attachment of thiol-containing ligands through stable thioether bonds.
- Liposome Functionalization: Enables incorporation of maleimide-functionalized phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a thiol-reactive lipid component for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports attachment of thiol-containing molecules to compatible lipid-containing nanoparticles.
- Surface Modification: Provides maleimide functionality for modification of compatible lipid and material interfaces.
- Biomaterial Research: Supports development of functional lipid conjugates, assemblies, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis.
DSPE-Maleimide (DSPE-Mal) combines a hydrophobic DSPE lipid anchor with thiol-reactive maleimide functionality and specifically provides a versatile platform for thiol conjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
