DBCO-Sulfo-Maleimide
This product is a bifunctional linker containing a dibenzocyclooctyne (DBCO) group and a sulfo-maleimide group. It specifically enables copper-free click chemistry with azides and selective thiol conjugation, providing a versatile tool for bioconjugation and probe development in aqueous environments.
Key Features and Benefits
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DBCO Group: Performs strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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Sulfo-Maleimide: Couples selectively with thiols under mild aqueous conditions.
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Water-Soluble Design: Sulfo functionality enhances solubility and biocompatibility.
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Dual Reactivity: Combines click chemistry with thiol-selective conjugation.
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High Purity: Ensures reliable performance in sensitive biological workflows.
Applications
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Bioconjugation: Links azide-modified and thiol-containing biomolecules.
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Probe Development: Builds multifunctional probes with bioorthogonal handles.
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Drug Delivery: Constructs PEGylated scaffolds with orthogonal conjugation points.
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Material Science: Functionalizes polymers and nanoparticles with dual chemistries.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use aqueous buffers or anhydrous solvents as required; avoid prolonged storage in solution.
This product combines copper-free click reactivity with thiol-selective sulfo-maleimide chemistry, specifically offering a highly soluble and versatile linker for bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
