DBCO-PEG1-amine is a bifunctional linker that features an azide-reactive dibenzocyclooctyne (DBCO) moiety, a hydrophilic polyethylene glycol (PEG) spacer, and an amine group. This unique combination facilitates bioconjugation through copper-free click chemistry, providing high selectivity, rapid reaction kinetics, and exceptional stability in various biological environments.
Introduction to the application:
DBCO-PEG1-amine is widely applied in pharmaceutical research and development for creating targeted drug delivery systems, bioimaging probes, and biomolecular conjugates. Its copper-free click chemistry property enables efficient bioorthogonal coupling, minimizing toxicity and interference in biological systems. This linker is particularly valuable for designing antibody-drug conjugates (ADCs), enhancing solubility and pharmacokinetics of therapeutic agents, and facilitating precise molecular interactions for improved therapeutic efficacy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
