DBCO-PEG1-acid
This product is a compact heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group, a short PEG1 spacer, and a terminal carboxylic acid. The DBCO enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides, while the carboxyl group couples efficiently with amines or activated esters. Its minimal PEG1 chain keeps the structure compact while maintaining solubility, making this reagent especially useful in space-limited bioconjugation workflows.
Key Features and Benefits
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DBCO Group: Enables ultrafast, copper-free click chemistry with azides.
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Carboxylic Acid Group: Couples readily with amines for stable amide bond formation.
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PEG1 Spacer: Provides minimal length with added hydrophilicity.
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Compact Design: Reduces steric hindrance in crowded biomolecular systems.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links azide- and amine-containing biomolecules.
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Protein and Antibody Labeling: Provides compact clickable handles for site-specific modification.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Serves as a PEGylated linker for targeted therapeutics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions before use; avoid prolonged exposure to aqueous buffers.
This product combines bioorthogonal click reactivity with amine-coupling functionality in a compact PEG1 scaffold, specifically offering an efficient tool for controlled conjugation and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
