BCN-PEG3-acid (CAS: 1807501-82-1) is a highly versatile compound used in bioconjugation, drug delivery, and various bio-orthogonal applications. It features a bicyclononyne (BCN) group, enabling copper-free click chemistry with azide-functionalized molecules, making it particularly suited for biological systems sensitive to copper.
Key Features:
- BCN Moiety: The BCN group allows for strain-promoted alkyne-azide cycloaddition (SPAAC), which reacts rapidly and selectively with azides in copper-free click reactions, ideal for live-cell labeling and in vivo studies.
- PEG3 Spacer: The polyethylene glycol (PEG3) chain improves water solubility, bioavailability, and reduces immunogenicity, making it a crucial component in drug formulations and biomolecule conjugation.
- Carboxylic Acid Group: The terminal carboxylic acid provides a reactive site for further conjugation, including forming stable amide bonds with amines, enabling the attachment of biomolecules like proteins, peptides, and surfaces.
Applications:
- Bioconjugation: BCN-PEG3-acid is commonly used in the labeling of biomolecules through copper-free click chemistry with azides, facilitating efficient and non-toxic reactions in biological systems.
- Drug Delivery: The PEG3 spacer enhances drug solubility, reduces aggregation, and improves pharmacokinetics, making it ideal for drug delivery systems that require biocompatibility and low immunogenicity.
- Nanotechnology & Surface Functionalization: It is widely applied in nanotechnology for functionalizing nanoparticles, surfaces, or materials, enabling further chemical modifications and enhancing bioavailability.
Benefits of BCN-PEG3-acid:
- Copper-Free Reaction: BCN reacts efficiently with azides without the need for copper catalysts, making it particularly suitable for sensitive biological systems.
- Improved Solubility: The PEG linker increases solubility, reducing potential issues like aggregation and improving biocompatibility.
- Flexible Conjugation: The PEG3 spacer allows for efficient and flexible molecule conjugation, providing versatility in various applications, from bioconjugation to drug delivery.
Storage and Handling:
- Storage: Store at -20°C in a dry and sealed container to prevent moisture absorption and preserve reactivity.
- Handling: Handle with care, following standard lab protocols to maintain stability and efficiency during reactions.
BCN-PEG3-acid is ideal for cutting-edge molecular biology, synthetic biology, and pharmaceutical development applications, offering a reliable and flexible solution for labeling, conjugation, and biocompatibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
