8-Arm PLGA-SH, MW 10K is a biodegradable multi-arm PLGA polymer with eight thiol-functionalized arms and an approximate molecular weight of 10 kDa where its branched architecture specifically supports conjugation, crosslinking, drug delivery, and advanced biomaterial applications.
Key Features and Benefits
- 8-Arm Architecture: Provides a branched polymer structure with multiple reactive arms.
- Thiol Functionalization: Offers terminal sulfhydryl groups for selective conjugation and crosslinking.
- MW 10K: Low molecular weight supports efficient processing and flexible formulation development.
- Biodegradable: PLGA segments degrade into lactic acid and glycolic acid under physiological conditions.
- Multivalent Platform: Multiple thiol groups enable efficient crosslinking and multifunctional modification.
Applications
- Bioconjugation: Thiol groups specifically enable coupling with maleimides and other thiol-reactive molecules.
- Drug Delivery: Supports biodegradable drug delivery and controlled-release carrier systems.
- Crosslinking: Enables formation of crosslinked polymer networks and biodegradable matrices.
- Hydrogels: Suitable for preparation of thiol-reactive and chemically crosslinked hydrogels.
- Biomaterials: Used in scaffolds, coatings, nanoparticles, and tissue engineering research.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container, protected from air and moisture.
- Handling: Minimize exposure to oxidizing conditions to reduce thiol oxidation and disulfide formation.
8-Arm PLGA-SH, MW 10K combines a branched eight-arm architecture with terminal thiol functionality, providing an especially versatile biodegradable platform for bioconjugation, crosslinking, drug delivery, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.