8-Arm PLGA-NHS, MW 40K is a biodegradable multi-arm PLGA polymer with eight NHS-activated arms and an approximate molecular weight of 40 kDa where its branched architecture specifically enables efficient amine coupling, crosslinking, drug delivery, and biomaterial applications.
Key Features and Benefits
- 8-Arm Architecture: Provides a branched polymer structure with multiple reactive arms.
- NHS Functionalization: Reacts efficiently with primary amines to form stable amide linkages.
- MW 40K: High molecular weight supports durable polymer networks and sustained-release formulations.
- Biodegradable: PLGA segments degrade into lactic acid and glycolic acid under physiological conditions.
- Multivalent Reactivity: Multiple NHS groups enable efficient conjugation and crosslinking with amine-containing molecules.
Applications
- Bioconjugation: Enables coupling with amine-containing proteins, peptides, ligands, and other biomolecules.
- Drug Delivery: Supports biodegradable controlled and sustained-release carrier systems.
- Crosslinking: Reacts with multi-amine compounds to form functional polymer networks.
- Hydrogels: Suitable for preparation of amine-crosslinked biodegradable hydrogel systems.\
- Biomaterials: Used in scaffolds, coatings, nanoparticles, and tissue engineering research.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container, protected from moisture.
- Handling: NHS groups are moisture-sensitive; prepare solutions immediately before use and minimize exposure to aqueous conditions before conjugation.
8-Arm PLGA-NHS, MW 40K combines a branched eight-arm architecture with amine-reactive NHS functionality, specifically providing a versatile biodegradable platform for bioconjugation, crosslinking, drug delivery, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.