4-Arm PLGA-NHS, MW 20K is a biodegradable branched PLGA polymer with four terminal NHS ester groups and an approximate molecular weight of 20 kDa. Its multivalent architecture specifically enables efficient amine conjugation, crosslinking, drug delivery, and biomaterial development.
Key Features and Benefits
- 4-Arm Architecture: Creates a branched structure with four functional PLGA arms.
- NHS Functionalization: Provides activated NHS ester groups that react efficiently with primary amines.
- MW 20K: Balances polymer processability with versatile formulation and material properties.
- Amine Reactivity: Forms stable amide bonds with amine-containing molecules under suitable reaction conditions.
- Multivalent Platform: Four NHS groups support efficient conjugation, crosslinking, and multifunctional polymer modification.
Applications
- Bioconjugation: Couples with amine-containing proteins, peptides, ligands, and other biomolecules.
- Drug Delivery: Supports biodegradable controlled and sustained-release carrier systems.
- Crosslinking: Reacts with multifunctional amines to create polymer networks and conjugates.
- Hydrogels: Forms biodegradable crosslinked networks with suitable amine-functionalized components.\
- Biomaterials: Supports functional nanoparticles, scaffolds, coatings, matrices, and other biodegradable materials.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container, protected from moisture.
- Handling: Minimize moisture exposure and prepare solutions shortly before use to limit NHS ester hydrolysis.
4-Arm PLGA-NHS, MW 20K combines biodegradable PLGA with four amine-reactive NHS groups to specifically support efficient bioconjugation, crosslinking, drug delivery, hydrogel formation, and advanced biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.