4-Arm PLGA-Mal, MW 40K is a branched, biodegradable PLGA polymer with four terminal maleimide groups. Its multivalent architecture specifically supports thiol-selective bioconjugation, crosslinking, drug delivery, hydrogel formation, and functional biomaterial development.
Key Features and Benefits
- 4-Arm Architecture: Provides four PLGA arms for multivalent functionalization and network formation.
- Maleimide Functionalization: Supplies terminal maleimide groups specifically for selective reactions with thiol-containing molecules.
- MW 40K: Supports durable polymer networks, particle formulation, and controlled-release applications.
- Thiol Reactivity: Maleimide groups react efficiently with sulfhydryl groups to form stable thioether linkages.
- Multivalent Platform: Four reactive termini enable efficient conjugation, crosslinking, and multifunctional polymer modification.
- Biodegradable: The PLGA segments undergo hydrolytic degradation into lactic acid and glycolic acid.
Applications
- Bioconjugation: Couples with thiol-containing peptides, proteins, ligands, and other functional molecules.
- Crosslinking: Builds biodegradable polymer networks using complementary thiol-functionalized components.
- Drug Delivery: Supports functional carriers, nanoparticles, and controlled-release systems.
- Hydrogels: Enables formation of biodegradable networks through maleimide-thiol crosslinking.
- Biomaterials: Supports scaffolds, coatings, matrices, and other functional biodegradable systems.
Storage and Handling
- Storage: Store at –20 °C in a fully sealed container under dry and dark conditions.
- Handling: Protect from moisture and excessive heat to preserve maleimide reactivity and polymer integrity.
4-Arm PLGA-Mal, MW 40K combines biodegradable PLGA with four reactive maleimide termini while its branched structure specifically supports thiol-selective conjugation, crosslinking, drug delivery, and advanced biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.