PEG methylamine linker (MeNH-PEG) features a methylamino group that reacts with carboxyl groups. It is ideal for bioconjugation, drug delivery, and material science. MeNH-PEG enhances solubility, reduces immunogenicity, and improves circulation time, making it versatile for various applications.
MeNH-PEG
MeNH-PEG (Methylamino-PEG), also known as a PEG Methylamine Linker, features a methylamino group (-NHCH3) at one end of the PEG chain. This functional group makes it useful for various applications in bioconjugation, drug delivery, and material science.
Key Features:
- Methylamino Group (-NHCH3): The methylamino group reacts easily with carboxyl groups or activated esters, forming stable amide bonds. As a result, it's ideal for linking biomolecules like proteins or peptides.
- PEG Chain: The PEG backbone improves solubility for hydrophobic drugs, proteins, and peptides in both water and organic solvents. It also helps reduce immunogenicity and increases circulation time in drug delivery systems.
Applications:
- Bioconjugation: MeNH-PEG links molecules to proteins, peptides, or antibodies through its reactive amine group, forming stable and effective conjugates.
- Drug Delivery: It modifies drug molecules or nanoparticles to boost solubility and prolong circulation time, enhancing drug delivery system performance.
- Material Science: MeNH-PEG coats materials to improve biocompatibility, reducing non-specific binding and increasing functional performance in various applications.