Methylamino-PEG-t-butyl ester is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a methylamino functional group (-NH-CH3) attached to one end of a PEG chain and a t-butyl ester group (-COO-tBu) at the other end.
Methylamino-PEG-t-butyl ester has been extensively used as a linker molecule for the conjugation of small molecules, peptides, and proteins to PEG. Its methylamino group can be used for the conjugation of molecules containing carboxyl or aldehyde groups, while the t-butyl ester group can be selectively removed by mild acid treatment to expose a carboxyl group for further conjugation. This versatile linker strategy has been used for the development of targeted drug delivery systems, imaging agents, and diagnostic tools.