N,N’-DME-N-PEG2-tert-butyl ester contains a methylamine and t-butyl ester end groups. The methylamine can undergo amide coupling with carboxylic acid or its activated esters. The t-butyl ester can under hydrolysis to form free acid for a second amide coupling with amine-bearing biomolecule. PEG together with the tertiary amine on the spacer improves the aqueous solubility of the resulting compound.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.