N,N’-DME-N-PEG-tert-butyl ester is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a tert-butyl ester group and a dimethoxyethane (DME) linker attached to the two ends of a PEG chain. The tert-butyl ester group is known for its ability to protect the amine group of the PEG chain from hydrolysis, while the DME linker enables water-solubility and stability in various solvents.
N,N’-DME-N-PEG-tert-butyl ester has been widely used in the field of pharmaceutical research and development due to its unique chemical properties. It is commonly utilized as a reagent for the synthesis of various drug conjugates, such as antibody-drug conjugates (ADCs) and peptide-drug conjugates (PDCs). The tert-butyl ester group can be easily cleaved under mild acidic conditions, releasing the free amine group for further conjugation with therapeutic agents, such as cytotoxic drugs or imaging agents.
In addition to its use in drug conjugation, N,N’-DME-N-PEG-tert-butyl ester can also be employed as a building block for the preparation of smart materials, such as hydrogels and supramolecular polymers. The DME linker provides flexibility and enables the formation of stable and responsive networks, while the PEG chain offers water-solubility and biocompatibility.