α‑Hydroxyl‑ω‑Azide‑poly(L‑lactide) (PLLA‑N₃, MW 5K) is linear, mono‑azide‑terminated semi‑crystalline biodegradable aliphatic polyester. The polymer backbone is composed of stereoregular L‑lactide repeating units and possesses inherent semi‑crystallinity, which is fundamentally different from fully amorphous PDLLA. Compared with low‑molecular‑weight PLLA‑N₃ analogues, this 5 kDa grade exhibits moderate hydrophobicity and intermediate hydrolytic degradation rate. One polymer terminus bears click‑reactive azide (‑N₃) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal azide participates in copper‑catalyzed azide‑alkyne cycloaddition (CuAAC) strain‑promoted azide‑alkyne cycloaddition (SPAAC) click reactions, enabling efficient covalent conjugation with alkyne‑, DBCO‑modified peptides, ligands and biomolecules under mild, bio‑friendly conditions. It functions as monofunctional click‑chemistry building block for medium‑degradation‑rate nanoparticle construction, surface azido‑modification and biodegradable biomedical delivery research.
Key Features
- MW: 5000 Da, linear α‑hydroxyl‑ω‑azide‑terminated poly(L‑lactide)
- Semi‑crystalline stereoregular L‑lactide structure, distinct from amorphous PDLLA
- Moderate hydrophobicity, intermediate and uniform hydrolytic degradation versus lower‑MW PLLA‑N₃
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivo
- Single terminal azide (‑N₃) click‑reactive group; compatible with CuAAC and SPAAC click chemistry; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high azide end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, acetone; insoluble in water
- Azide‑terminated polymer; avoid strong impact, high‑temperature heating and heavy‑metal contaminants; store away from shock sources
Applications
- Monofunctional click‑chemistry building block for bioconjugation with alkyne / DBCO‑activated peptides, targeting ligands and biomacromolecules
- Fabrication of azide‑functional PLLA nanoparticles and micelles with medium degradation speed for drug‑delivery research
- Azido surface functionalization of semi‑crystalline polyester materials for subsequent bio‑orthogonal modification
- Precursor for synthesizing PLLA‑based click‑derived block and graft copolymers
- Research‑grade raw material for bio‑orthogonal modified degradable biomedical polymer study
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof, avoid shock and excessive heating
- Keep hermetically sealed; moisture accelerates polyester backbone hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.