PLLA-Amine (PLLA-NH2), MW 20K is an amine-functionalized poly(L-lactide) with a molecular weight of approximately 20K. It combines a biodegradable PLLA backbone with terminal primary amine functionality specifically for bioconjugation, polymer functionalization, surface modification, drug delivery, and biomaterial research.
Key Features and Benefits
- Amine-Functionalized PLLA: Combines biodegradable poly(L-lactide) with a terminal primary amine group for chemical modification and conjugation.
- MW 20K: Provides a moderate molecular weight that balances polymer processability, biodegradable matrix formation, and functionalization.
- Primary Amine Functionality: The terminal –NH2 group provides a reactive site for coupling with carboxyl, NHS ester, isocyanate, and other amine-reactive functionalities.
- Biodegradable Polyester: The PLLA backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Stereoregular PLLA Backbone: The L-lactide-derived polymer structure promotes crystallinity and provides useful structural and thermal properties.
- Versatile Conjugation Platform: Terminal amine functionality supports attachment of compatible polymers, biomolecules, ligands, probes, and other functional components.
- Polymer Modification: The reactive amine terminus enables preparation of functional PLLA derivatives and more complex polymer architectures.
Applications
- Bioconjugation: Provides terminal amine functionality for coupling PLLA with compatible biomolecules, ligands, and functional molecules.
- Amide Coupling: Supports conjugation with carboxyl-containing compounds using appropriate coupling chemistry.
- NHS Ester Conjugation: Reacts with NHS ester-functionalized molecules, polymers, and surfaces to form stable amide linkages.
- Polymer Functionalization: Enables preparation of functional PLLA derivatives, block polymers, and other polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Provides a reactive amine group specifically for attachment to compatible functionalized surfaces and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems specifically for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLLA-Amine (PLLA-NH2), MW 20K provides a biodegradable PLLA platform with terminal primary amine functionality for conjugation and polymer modification and specifically supports bioconjugation, nanoparticle functionalization, surface modification, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.