α‑Hydroxyl‑ω‑Azide‑poly(L‑lactide) (PLLA‑N₃, MW 20K) is linear, mono‑azide‑terminated semi‑crystalline biodegradable aliphatic polyester. Constructed from stereoregular L‑lactide repeating units, the polymer exhibits high crystallinity, which is fundamentally different from fully‑amorphous PDLLA. Within the PLLA‑N₃ product series, this 20 kDa grade possesses the highest hydrophobicity and delivers ultra‑slow homogeneous hydrolytic degradation performance. One polymer terminus carries click‑reactive azide (‑N₃) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal azide supports copper‑catalyzed azide‑alkyne cycloaddition (CuAAC) and strain‑promoted azide‑alkyne cycloaddition (SPAAC) bio‑orthogonal click reactions, enabling efficient covalent conjugation with alkyne‑ or DBCO‑modified peptides, targeting ligands and biomolecules under mild conditions. It serves as monofunctional click‑chemistry building block for ultra‑slow‑degrading microspheres, implant‑oriented porous scaffolds and ultra‑long‑term sustained‑release biomedical research.
Key Features
- MW: 20000 Da, linear α‑hydroxyl‑ω‑azide‑terminated poly(L‑lactide)
- Semi‑crystalline high‑order stereoregular L‑lactide structure, distinct from amorphous PDLLA
- Highest hydrophobicity in PLLA‑N₃ series, ultra‑slow and uniform hydrolytic degradation
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivo
- Single terminal azide (‑N₃) click‑reactive group; compatible with CuAAC and SPAAC bio‑orthogonal reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high azide end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Azide‑terminated polymer; avoid strong mechanical impact, high‑temperature heating and heavy‑metal contaminants; store away from shock sources
Applications
- Monofunctional click‑chemistry building block for bioconjugation with alkyne / DBCO‑activated peptides, targeting ligands and biomacromolecules
- Fabrication of azide‑functional high‑crystallinity PLLA microspheres and tissue‑engineering porous scaffolds for ultra‑long‑term sustained‑release drug‑delivery research
- Azido surface functionalization of implant‑grade polyester materials for subsequent bio‑orthogonal grafting modification
- Precursor for synthesizing high‑molecular‑weight PLLA‑derived click‑based block and graft copolymers
- Research‑grade raw material for bio‑orthogonally‑modified implant‑related degradable biomedical polymer study
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof, avoid shock and excessive heating
- Keep hermetically sealed; humidity accelerates polyester backbone hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.